By J.W. Gorrod, P. Jacob III
This ebook presents for the 1st time a unmarried complete resource of data at the analytical chemistry of nicotine and comparable alkaloids. The editors have introduced jointly scientists from academia and the tobacco to explain the cutting-edge of the chemistry and analytical tools for size of nicotine. either the scope and element of the ebook are awesome. Chapters describe the heritage, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and different alkaloids within the tobacco plant, the final chemistry of nicotine and the analytical methodologies which have been used to degree nicotine and similar alkaloids in organic specimens, in tobacco and pharmaceutical items and in tobacco smoke. there's additionally a finished evaluate of the chemistry and toxicology of nicotine-derived nitrosamines, an enormous type of tobacco cancer causing agents.
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Extra info for Analytical Determination of Nicotine and Related Compounds and their Metabolites
Enantiomeric composition of nornicotine, anatabine, and anabasine in tobacco. Chirality, 1999: 11; 82-84. 46 Leete E, Muller ME. Biomimetic synthesis of anatabine from 2,5-dihydropyridine produced by the oxidative decarboxylation of baikiain. J. Am. Chem. , 1982: 104; 6440-6444. 47 Herminghaus S, Tholl D, Rugenhagen C, Fecker LF, Leuschner C, Berlin J. Improved metabolic action of a bacterial lysine decarboxylase gene in tobacco hairy root cultures by its fusion to rbsS transit peptide coding sequence.
Integration events ranged from one in N. cavicola and N. africana to as many as six in N. rustica. The alkaloid contents of cultures were measured at suitable times, and compared with the alkaloids of untransformed plants of the same species. The number of integrations of T-DNA did not proportionately affect alkaloid contents. Hairy root cultures of all seven transformed species contained significantly greater amounts (fresh weight basis) of nicotine, nornicotine, anatabine and anabasine than did roots of untransformed plants, grown aseptically on agar or in soil.
Pot-bound plants respond to leaf damage in an attenuated manner. However, upon transplanting ('releasing') such plants to larger pots, the nicotine response to leaf damage was manifested . The signal elicited in the leaf is a chemical rather than electrical one, and is a positive (initiation of production), rather than a negative (cessation of production), cue . It is transmitted from damaged parts via the phloem to the root, as indicated by stem-girdling experiments: damaging leaves above the girdle produces no additional alkaloid production; damaging leaves below the girdle results in an increased alkaloid delivery to the entire plant through the xylem stream.
Analytical Determination of Nicotine and Related Compounds and their Metabolites by J.W. Gorrod, P. Jacob III