By Gordon M. L. Cragg, David Kingston, David J. Newman
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53. , Isolation and structure of combretastatin D-1: a cell growth inhibitory macrocyclic lactone from Combretum caffrum, J. Am. Chem. , 110, 8539, 1988. 54. B. , Antineoplastic agents. 206. Structure of the cytostatic macrocyclic lactone combretastatin D-2, J. Org. , 55, 2797, 1990. 55. , McGraw-Hill, New York, 1978. 56. , Structure of the α,β-tubulin dimer by electron crystallography, Nature, 391, 199, 1998. 57. , Direct photoaffinity labeling of tubulin with taxol, J. Natl. , 84, 785, 1992. 58.
Application WO2002102766 A2, 2002. 27. R. B, Combretastatin A-4, US Patent 4,996,237, 1991. 28. R. , Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated “combretastatins,” US Patent 5,569,786, 1996. 29. Pettit, G. , Combretastatin A-4 prodrug, US Patent 5,561,122, 1996. 30. Pinney, K. G. , Description of anti-mitotic agents which inhibit tubulin polymerization, US Patent 6,350,777, 2000. 31. R. , Synthesis of hydroxyphenstatin and the prodrugs thereof as anticancer and antimicrobial agents, PCT Int.
A fifth study (phase I/II) recently initiated is CA4P in combination with the 131I-radiolabeled anti-CEA antibody A5B7 for the treatment of colorectal carcinoma. A sixth study (phase I/II) soon to be initiated is CA4P in combination with doxorubicin, cisplatin, and radiotherapy for the treatment of newly diagnosed anaplastic thyroid carcinoma. Combretastatin A-1P (Oxi-4503) has also shown excellent activity in preclinical studies. , phase Ib with carboplatin). 166 VIII. CODA In the classic 1962 compilation and discussion of “Medicinal and Poisonous Plants of Southern and Eastern Africa,” Watt and Breyer-Brandwijk described the root bark of C.
Anticancer Agents from Natural Products by Gordon M. L. Cragg, David Kingston, David J. Newman