By National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Biologic Markers, Subcommittee on Immunotoxicology
Are environmental toxins threatening the human immune procedure? Researchers are quickly imminent definitive solutions to this query, by using biologic markers - subtle evaluate instruments which can revolutionize detection and prevention of convinced ailments. This quantity, 3rd in a sequence on biologic markers, makes a speciality of the human immune process and its reaction to environmental toxicants. The authoring committee presents course for carrying on with improvement of biologic markers, with innovations for utilising markers to immunotoxicology in people and urged outlines for scientific and box experiences. This accomplished, updated quantity could be worthy to experts in toxicology and immunology and to biologists and investigators enthusiastic about the improvement of biologic markers.
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Extra info for Biologic Markers in Immunotoxicology
In addition, because of their relatively short half-lives, they must be measured within short times after exposure. , 1987a). The variability between individuals and the influence of the factors affecting sensitivity greatly influence the ability of the markers to detect those individuals exposed. Some markers that are validated generally have been established only for obvious clinical events. , 1988). Reference ranges for adult and pediatric populations have been established, so it is known that these levels show wide normal variation between individuals.
Photohypersensitivity is a major concern in immunotoxicology but was beyond the scope of this report. Only a few chemicals have been tested for photoactivation to produce a structure that elicits a contact hypersensitivity response. The role and mechanisms of chemical-induced photosensitization also require further investigation. In addition, because light might have a role as an immunosuppressant, gathering additional information about the role that the immune system might have on development of skin tumors seems warranted.
These analytic considerations are complicated by the intrinsic variability of the immune system within and between individuals, making the sensitivity and specificity of many tests for immune-system markers modest to poor. Optimizing the analytic specificity and sensitivity of current assays and developing new assays with better specificity and sensitivity also should be given the greatest possible attention. A major purpose of markers in environmental health research is to identify exposed persons, so that risk can be predicted and disease prevented.
Biologic Markers in Immunotoxicology by National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Biologic Markers, Subcommittee on Immunotoxicology