By Shannon R. Blume, Kuei Y. Tseng (auth.), Kuei-Yuan Tseng (eds.)
Cortico-subcortical dynamics in Parkinson’s affliction goals to combine key pathophysiological points underlying Parkinson’s affliction. the quantity bargains a wide spectrum of evaluations on how continual dopamine depletion impacts cortico-subcortical dynamics, specifically how disruptions of the non-dopaminergic platforms as a result of continual dopaminergic degeneration may lead to the practical adjustments saw in parkinsonism.
About the Editor:
Dr. Kuei Y. Tseng is Assistant Professor within the division of mobile and Molecular Pharmacology at Rosalind Franklin collage of drugs and technology, The Chicago scientific college, North Chicago, IL, USA.
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Additional resources for Cortico-Subcortical Dynamics in Parkinson's Disease
PQ can cause small, but significant, losses of SN DA neurons [78–81]. PQ administration upregulates alpha-synuclein and induces its aggregation [82, 83]. Maneb (manganese ethylenebisdithiocarbamate), a fungicide that inhibits glutamate transport and disrupts DA uptake and release, is generally co-administered with PQ subchronically to enhance toxicity [84–86]. When combined with maneb, PQ can destroy 50% of SN DA neurons in young mice , but in older mice (18 months of age), the combined treatment produces a more progressive DA cell loss (approximately 75% at 2 weeks and 88% at 12 weeks) .
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J Neurosci 2003;23(15):6351–6. 34. Pillon B, Czernecki V, Dubois B. Dopamine and cognitive function. Curr Opin Neurol 2003;16 Suppl 2:S17–22. 35. Cenci MA, Whishaw IQ, Schallert T. Animal models of neurological deficits: how relevant is the rat? Nat Rev Neurosci 2002;3(7):574–9. 36. Meredith GE, Sonsalla PK, Chesselet MF. Animal models of Parkinson’s disease progression. Acta Neuropathol 2008;115(4):385–98. 37. Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson’s disease.
Cortico-Subcortical Dynamics in Parkinson's Disease by Shannon R. Blume, Kuei Y. Tseng (auth.), Kuei-Yuan Tseng (eds.)