By Gerald Ankley, Ann Miracle, Edward J. Perkins, George P. Daston
Fueled in part by means of huge, well-publicized efforts corresponding to the Human Genome undertaking, genomic learn is a speedily turning out to be sector in a number of organic disciplines, together with toxicology. a lot of this strength, in spite of the fact that, has been mentioned within the literature and at technical conferences simply in quite extensive phrases, making it tricky to evaluate precisely how info generated from new genomics applied sciences may perhaps truly influence or profit the danger evaluate method.
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Extra info for Genomics in Regulatory Ecotoxicology: Applications and Challenges
The endpoints for ERA screening assays are selected by various criteria such as the intended use of the chemical, the anticipated route and duration of exposure, and the bioavailability of the chemical. Considering the multitude of chemicals and situations that need to be considered for ecological testing, it seems logical that genomic technologies could play a role in screening and prioritizing within a regulatory ERA framework. From a prospective ERA stance, the registration of new chemicals can sometimes be best described as a “shot in the dark”.
Ecotoxicogenomics: the challenge of integrating genomics into aquatic and terrestrial ecotoxicology. Aquat Toxicol 67:143–154. [SETAC] Society of Environmental Toxicology and Chemistry. 1992. Biomarkers—biochemical, physiological, and histological markers of anthropogenic stress. SETAC Special Publications Series. Ann Arbor (MI): Lewis. Stentiford GD, Viant MR, Ward DG, Johnson PJ, Martin A, Wenbin W, Cooper HJ, Lyons BP, Feist SW. 2005. Liver tumors in wild flatfish: a histopathological, proteomic and metabolomic study.
2006). Stress gene responses: The transcriptional responses of 14 stress promoter or response element chloramphenicol-acetyl transferase (CAT) fusion constructs that are stably integrated into human carcinoma HepG2 cells show considerable promise as a multiple endpoint assay (Todd et al. 1995). Applications range from testing metals (Mumtaz et al. 2002; Tchounwou et al. 2003) to compounds with military use (Miller et al. 2004) to air pollutants (Vincent et al. 1997; Goegan et al. 1998). 1 International Efforts by Government and Industry Government departments and agencies worldwide are now expressing interest in the possible application of genomic technologies to the development of new screening methods.
Genomics in Regulatory Ecotoxicology: Applications and Challenges by Gerald Ankley, Ann Miracle, Edward J. Perkins, George P. Daston